Journal of Clinical Research

Dr, Department of Immunology, School of Medicine affiliated Ruijin Hospital, Shanghai Jiao Tong University, Buffalo, NY, USA

Publications

• Research Article   
  Buerger's Disease: Autoimmune Disease Involving Multiple Hypersensitivity Types
  Author(s): Portia Ping Zheng* and Wanchao Wang
  
  Background: Burger’s disease is an autoimmune disease? And what is the immunological pathogenesis? It has not been deeply researched but still attracts the attention of scholars. In our early study we reported that TAO may be an autoimmune disease involving hypersensitivity Type III and Type IV. Methods: In this study we further explored the immune pathogenesis of TAO based on initial research. Results: We detected humoral immunity (Ig E) in 28 cases using Enzyme-Linked Immunosorbent Assay (ELISA). Antigen-antibody complex depositing on the vessel wall in 18 cases, and anti-vessel antibodies in 28 cases using three kinds of immune-labeling techniques (immunofluorescence labeling, immunoenzymatic staining and immuno-gold-silver staining). The result shows Ig E levels were significantly high (P<0.01). As high as.. Read More»
  

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