Molecular and Genetic Medicine

Department of Clinical Pharmacy, Square Hospitals Ltd., West Panthapath, Dhaka, Bangladesh

Publications

• Research Article   
  High Dose Tigecycline-Induced Mitochondrial Dysfunction-Associated Acute Metabolic Acidosis: A Retrospective Study
  Author(s): Hasan MJ*, Rabbani R, Bachar SC and Huq SMR
  
  Background: Tigecycline (TGC) is a last resort antibiotic having broad spectrum antibacterial activity against gram-negative bacteria. Beyond its standard dosing regimen, a double dosing regimen has been practicing for last couple of years to achieve adequate drug concentration in the targeted body tissues. TGC interferes with the mitochondrial protein translation process and may lead to non-anion gap acute metabolic acidosis (NAGAMA) with low blood-pH level. The main objective of this retrospective study was to evaluate the frequency of high dose TGCinduced NAGAMA events in the South Asian critically ill patients. Methods: The retrospective data of 24 critically ill patients of an intensive care unit (ICU) were considered for this study. Patients of this study received high dose of TGC. Including all necessary laborato.. Read More»
  

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