Department of Translational Medicine & Therapeutics, HealthCare Global Enterprises Ltd (HCG), Bengaluru, Karnataka, India
Research Article
A Correlation of Pathological Characteristics and Immunohistochemistry
(IHC) Based Biomarker Expression in Triple Negative
Breast Carcinomas
Author(s): Priyanka Maheshwari, Rajesh Kumar KS*, Diganta Hazarika and Radheshyam Naik
Background and aim: Triple-negative Breast Cancer (TNBC) is defined as a group of breast carcinomas that are negative for expression of
hormone receptors Estrogen Receptor (ER) or Progesterone Receptor (PR) and Human Epidermal Growth Factor Receptor 2 (Her2). In India,
several reports have suggested that TNBC incidence is higher and up to 31%. Histological features of triple-negative breast cancer are reported to
be common with those of basal-like subtype, comprising of high-grade invasive ductal carcinoma, no special type, invasive ductal carcinoma with a
large central acellular zone, typical medullary carcinoma, and metaplastic carcinomas. In the present study, we aimed to correlate the pathological
characteristics and evaluate IHC based expression of basal type biomarkers in triple negative breast carcinomas. Our study showed heterogeneity
i.. Read More»
Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report
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