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Medicinal Chemistry

ISSN: 2161-0444

Open Access

Ramesh Ennam

Department of Organic Chemistry, Vaageswari Institute of Pharmaceutical Sciences, Ramakrishna Colony, Karimnagar, Telangana, India

Publications
  • Research   
    2-(Aryl Oxy Methyl)-1H- Benzimidazoles: Synthesis, Characterization and Biological Evaluation
    Author(s): Rekhala John Sunil*, Ramesh Ennam, Sunitha Tharigoppula, Pal Sarbani and Jayashree Ani Reddy

    Helminthiasis is a macro, parasitic disease of humans and animals in which a part of the body is infected with Helminth parasites. It is one of the most deadly, neglected, tropical diseases and many die annually from this disease. The total eradication from this problem is very difficult. The drugs which expel Helminth parasites from the body either by stunning or killing them without causing significant damage to the host are called Anthelmintics. The most commonly used class of Anthelmintics are Benzimidazoles, whose mode of action is by blocking transportation of secretory granules and movement of other cell organelles by binding to beta-tubulin and inhibit polymerization of microtubules in the cytoskeleton of the Helminthic parasite. Most of the Anthelmintics are non-selective, with a narrow spectrum of activity, high toxicity, unsafe for undernourished children and pregnant women.. Read More»
    DOI: 10.37421/2161-0444.2020.10.549

    Abstract HTML PDF

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Citations: 6627

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