Journal of Blood & Lymph

3National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton Foundation Trust, Southampton SO16 6YD, United Kingdom

Publications

• Mini Review   
  Cytotoxic Non-TH2 CD4+ T Cells are Associated with Asthma Severity
  Author(s): Sara Herrera-De La Mata, Syed Hasan Arshad, Ramesh J Kurukulaaratchy and Grégory Seumois*
  
  Patients with severe uncontrolled asthma represent a distinct endotype with persistent airway inflammation and remodeling that is refractory to corticosteroid treatment. CD4+ TH2 cells play a central role in regulating asthma pathogenesis, and biologic therapies targeting their cytokine pathways have had promising outcomes. However, not all patients respond well to such treatment, and their effects are not always durable nor reverse airway remodeling. This observation raises the possibility that other CD4+ T cell subsets and their effector molecules may drive airway inflammation and remodeling. We performed single-cell transcriptome analysis of >50,000 airway CD4+ T cells isolated from Bronchoalveolar Lavage (BAL) samples from 30 patients with mild and severe asthma. We observed striking heterogeneity in the nature of CD.. Read More»
  

  Abstract PDF