Journal of Anesthesiology and Pain Research

Department of Anesthesiology & Pain Medicine, University of Berlin, 14195 Berlin, Germany

Publications

• Mini Review   
  Drug Metabolism of Monoclonal Antibodies and Nanoparticles is Influenced by Anesthesia
  Author(s): Reena Williams*
  
  Following absorption, drugs circulate throughout the body in part to reach target tissues and in part to be eliminated from regions where they have no clinically significant impact. Therapeutically relevant drug effects typically come to an end with drug metabolism and/or elimination. The generally thought to play a minor part in these essential pharmacokinetic processes was the spleen. Although this organ is anticipated to be extensively exposed to massive, new generation medications that cannot permeate other tissues with tight endothelial barriers due to its high blood flow and microcirculation properties. The spleen receives very little attention in textbooks on pharmacology, and among its physiological functions—such as immunological monitoring, the elimination of old blood cells, hematopoiesis, and blood volume regulation—neither drug disposition nor involv.. Read More»
  DOI: 10.37421/ 2684-5997.2022.05.157

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