Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada
Mini Review
Epidemiology and Risk Factors of Polycystic Kidney Disease
Author(s): Ria Ramona*
Polycystic Kidney Disease (PKD) represents a group of inherited disorders characterized by the development of numerous fluid-filled cysts
within the kidneys. This review explores the epidemiology and risk factors associated with PKD, focusing on both autosomal dominant (ADPKD)
and autosomal recessive (ARPKD) forms. ADPKD, primarily caused by mutations in the PKD1 and PKD2 genes, affects approximately 1 in
400 to 1,000 individuals globally, making it one of the most common genetic disorders affecting the kidneys. ARPKD, less prevalent yet severe,
manifests early in life due to mutations in the PKHD1 gene.
Risk factors for PKD include family history, with ADPKD showing variable penetrance and genetic mutations leading to abnormal cystic
proliferation in renal tissue. Clinical manifestations vary widely, from asymptomatic cysts to progressive renal failure, ne.. Read More»
DOI:
10.37421/2684-494X.2024.9.231
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 