Department of Math and Science, Regent University, Virginia,, USA
Review Article
The Mechanism Of VDJ Recombination In The Human Immune System
Author(s): Rostern Tembo*
During the maturation of every B cell and T cell in the body, there exists a process known as VDJ recombination, which acts to instate a drastic change in the cells’ genetic makeup. The purpose of the process is to completely randomize the way the genes are arranged so that the consequential immunoglobulins and T cell receptors can take on wildly different conformations, effectively preparing for the infinite possibilities of invasions that will inevitably occur. Taking only one of each of the numerous V, D, and J segments within a locus, proteins involved in the recombination function to bring said segments adjacent to one another, cleave off their ends, and attach them side by side via extra nucleotides placed in between them. As it is the process solely responsible for the body’s ability to protect and effectively memorize a plethora of different pathogens, ant.. Read More»
DOI:
10.37421/2572-4134.2024.10.254
Journal of Food & Industrial Microbiology received 160 citations as per Google Scholar report