Department of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA
Research Article
Synergistic Inhibition of HIV-1 Replication by a Combination of Viral Inhibitors Isolated from Compounds Targeting Viral Entry, Integration and Proviral Transcription of Clinical Isolates and Drug-resistant Strains
Author(s): Ibrahim S. Abd-Elazem, Kiattisak Lugsanangarm, Nadtanet Nunthaboot and Ru Chih C. Huang*
Background: Drug resistance associated with HIV-1 variants emerges due to undetected treatment failures. Therefore, it is urgent to search
for an antiretroviral therapy to control HIV replication. We examined the synergistic inhibition of HIV-1 replication by a combination of potential
inhibitors against clinical isolates and drug-resistant strains.
Methods: Nontoxic, natural product-derived inhibitors, the viral entry inhibitor (Gen-1 (tieghemelin, a triterpenoid saponin)), the integrase inhibitor
(M522 (lithospermic acid)), and the transcription inhibitors (G4N (tetraglycylated NDGA) or M4N (tetra-O-methyl-NDGA, terameprocol)) were
used to target viral entry, integration, and transcription steps. They have been tested against the replication of an AZT-resistant strain of HIV-1 and
clinical isolates from HIV-infected patie.. Read More»
DOI:
10.37421/2155-6113.2024.15.1031
Journal of AIDS & Clinical Research received 5264 citations as per Google Scholar report