Molecular Biology: Open Access

Department of Pharmacology, NITTE University, Karnataka, India

Publications

• Research   
  Association of Leptin Gene Polymorphism with Metabolic Parameters in Gestational Diabetes Mellitus: A Cross-sectional study
  Author(s): Usha Adiga*, Nandit Banawalikar P, Sachidananda Adiga MN, Desy TM and Lakshmi Manjeera
  
  Background: Gestational diabetes mellitus (GDM) is a complication of pregnancy that is characterized by impaired carbohydrate tolerance as a result of insulin resistance. Objective was to find association between leptin gene with leptin levels, insulin resistance as well as lipid profile in GDM patients as compared to normal glucose tolerant pregnant women. Method: In this cross-sectional study, 100 GDM patients and 100 gestational age and BMI-matched healthy pregnant women were included. Genotyping of leptin gene LEPG2548A (rs7799039) was performed by PCR-RFLP. Biochemical parameters were estimated. Various insulin resistance models were constructed using suitable homeostasis model assessment formulae. Chi-square test was used to investigate the associations, Mann Whitney U test to compare biochemical parameters, Spearman&.. Read More»
  DOI: 10.37421/2168-9547.2022.11.354

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