Journal of Forensic Research

Department of Molecular Biology, University of Fortaleza, Fortaleza, Brazil

Publications

• Full Length Research Paper   
  Evaluation of the Association of the Renalase rs10887800 Polymorphism with the Risk of Preeclampsia in Brazilian Women
  Author(s): Jose Juvenal Linhares*, Mara Suellem de Freitas Moura, Emmanuelle Coelho Noronha, Wanneida Christina de Pina Fernandes, Kaio César Simiano Tavares, Andrẵ Saraiva Leão Marcelo Antunes and Samara Casemiro Benevides
  
  Despite advances in obstetric medicine, the pathogenesis of preeclampsia (PE) remains poorly understood. It has been suggested that PE results from a state of sympathetic hyperactivity with circulating catecholamines increased in this condition. A new enzyme, called Renalase, has recently been identified exhibiting activity on the metabolism of catecholamine and blood pressure reduction when administered in vivo. Thus, this study evaluated the possible association between the presence of the Renalase gene (RNLS) (rs10887800) polymorphism and mechanisms that control the pathogenesis of PE. This was a cross-sectional, quantitative, case-control study with 94 pregnant women with PE (cases) and 97 normotensive pregnant women (controls). A standardized form was used to collect demographic and clinical data; oral scraping samples were collected, and DNA extraction and subsequent real-time p.. Read More»
  

  Abstract PDF