Journal of Computer Science & Systems Biology

Department for General Pathology and Pathological Anatomy, Faculty of Medicine, University of Rijeka, Cambierieva ul. 17, 51000 Rijeka, Croatia

Publications

• Research Article   
  Evaluation of the Efficacy of Cancer Drugs by Using the Second Largest Eigenvalue of Metabolic Cancer Pathways
  Author(s): Drasko Tomic*, Karolj Skala, Lado Kranjcevic, Boris Pirkic, Sanja Stifter and Iva Smit
  
  Cancer is a system with thousands of genes and proteins with the complex interactions between them. By examining the cancer drug activity on only part of this system, we do not know in which direction the whole system will evolve, and whether therapy will be useful or not. This is one of the main reasons why cancer therapies still do not meet our expectations. In order to find more effective anticancer therapies, it is important to consider the impact of drugs on the entire cancer system. The second largest eigenvalue plays a key role in complex systems optimization. The algorithms minimizing the second largest eigenvalue of graphs have been already used to speed up processes in computer networks and differential cryptanalysis. Based on the aforementioned, it could be assumed that maximizing the second highest eigenvalue could slow down the processe.. Read More»
  

  Abstract PDF