Molecular and Genetic Medicine

Laboratory of Clinical Cytology, Cytogenetics and Biology of Reproduction, Aristide Le Dantec Hospital, Dakar, Senegal

Publications

• Research Article   
  Association of the TP53 Arg72Pro Polymorphism with Oral Squamous Cell Carcinoma: A Meta-Analysis
  Author(s): Sarr PD, Ba Sa, Toure S, Diop JPD, Dia Y, Mbengue B, Sylla Niang M, Faye O, Dieye A and Ndiaye Diallo R*
  
  Background: The loss of function in TP53 gene is an early event of carcinogenesis and is now considered as a full etiological factor in oral squamous cell carcinoma (OSCC). The most common polymorphism in this gene that is associated to OSCC and has been extensively studied as a potential risk factor for the development of malignancies is the single nucleotide polymorphism (SNP) encoding either proline or arginine at residue 72. Today, despite the multiplicity of publications and approaches used, the contradiction of the results have not remove the ambiguity of the possible impact of this polymorphism in OSCC. So we aimed this meta-analysis to investigate the distribution of TP53 codon 72 genotypes and alleles in patients with OSCC and healthy matched controls, by using an ethnicity subgroups analysis. Method: A literature search was conducted.. Read More»
  DOI: 10.37421/jmgm.2020.14.455

  Abstract HTML PDF