Journal of Blood & Lymph

Department of Sensory and Motor System Medicine, The University of Tokyo, Tokyo, Japan

Publications

• Mini Review   
  Concise Review: Selecting the Source of Mesenchymal Stem Cells for Cartilage Regeneration Therapy
  Author(s): Satoshi Miwa, Ryota Chijimatsu*, Hideshi Ishii and Taku Saito
  
  Mesenchymal stem/stromal cells (MSCs) have been widely studied for regeneration therapy in various organs/diseases and are currently being developed for clinical practice. Despite the hope brought by MSC therapy, the characteristics of MSCs remain ambiguous, where cells have distinct features depending on their sources and species. With regard to cartilage therapy, MSCs from the bone marrow and synovium have been clinically examined based on their differentiation into chondrocytes in animal studies. However, recent studies have outlined other reparative mechanisms of MSCs, such as paracrine effects. Thus, the regeneration mechanisms are still elusive, and the key features of MSCs that determine their reparative activity have not been established. In this review, we summarize the current literature and discuss the importance of the assays to evaluate “human&rdqu.. Read More»
  DOI: 10.37421/2165-7831.2021.11.266

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