Clinical Gastroenterology Journal

Department of Gastroenterology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India

Publications

• Research Article   
  Efficacy and Safety of Tenofovir Alafenamide in Treatment Naive Patients with Hepatitis B-Virus Related Decompensated Cirrhosis: A Prospective Observational Study
  Author(s): Sanjeev Jha*, Ravikant Kumar, Saurabh Kumar, Ravi Keshri, Aditya V. Singh, Gaurav Kumar and Samir S. Bhagwat
  
  Background: The effect of Tenofovir Alafenamide (TAF) therapy on viral suppression and hepatic function in patients of Hepatitis B Virus (HBV) related decompensated cirrhosis is not known. Aim of this study was to evaluate the efficacy and safety of TAF therapy in these patients. Methods: We analyzed 55 consecutive HBV-infected treatment naive patients with decompensated cirrhosis treated with 25 mg/day TAF and evaluated the treatment outcomes. Treatment efficacy was evaluated by measuring virological, serological, biochemical responses and changes in hepatic function over period of 6 month. Results: At month 6, undetectable HBV-DNA level, HBeAg loss, HBeAg seroconversion and ALT normalization was seen in 65.2%, 22.2%, 5.5% and 74.5% patients respectively. Virological and biochemical responses were simi.. Read More»
  DOI: 10.37421/cgj.2021.6.143

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