Department of Pharmaceutical Chemistry, National College of Pharmacy, Kerala, India
Review Article
Review on Anti−Cancer Potential of Novel Imidazothiazoles and their Synthetic Methods
Author(s): Vajid Parasuraman Kunnath*, Shadiya Chediyan Kandy and Akash Marathakam
In recent studies on cancer treatment, researchers find out that several enzymatic mutations lead to the development of cancerous cells. Such
as Indoleamine 2,3-dioxygenase 1 (IDO1), B-Raf kinase, and ErB4 (HER4) kinase inhibitors. Imidazothiazole-based derivatives are gained more
attention among scientists due to their wide variety of pharmacological activities, such as anti-fungal, anti-bacterial, anthelmintic, and anti-cancer
activities as well as ease of synthesis of these compounds. During the search for compounds that can act as anti-neoplastic agents through inhibition
of these enzymatic receptors, researchers found that imidazothiazole-based compounds and their derivatives show more potent anticancer activity.
In this review, we focus on some traditional synthetic methods proposed by researchers to prepare imidazothiazole derivatives and their anticancer
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DOI:
10.37421/2161-0444.2023.13.674
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