Journal of Applied & Computational Mathematics

Department of Mathematics, University of Dhaka, Shahbag, Bangladesh

Publications

• Mini Review   
  Using Mathematics to Estimate the Affinity of Aptamer Target Binding
  Author(s): Shaik Yusuf*
  
  In the intricate realm of molecular interactions, the utilization of mathematics plays a pivotal role in deciphering and predicting the affinity of aptamer-target binding. Aptamers, short single-stranded nucleic acids or peptides, have emerged as versatile molecular recognition elements, showcasing an inherent ability to selectively bind to specific target molecules with remarkable affinity. The estimation of this binding affinity is a complex task that necessitates a sophisticated mathematical framework. Central to this estimation is the application of thermodynamics, where mathematical models are employed to unravel the energetic landscape of aptamer-target interactions. Thermodynamic parameters such as Gibbs free energy, enthalpy, and entropy are harnessed to quantify the driving forces behind binding events. The affinity constant, often represented by Kd, s.. Read More»
  DOI: 10.37421/2168-9679.2023.12.530

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