Research and Reports in Medical Sciences

Cairo University, Egypt

Publications

• Extended Abstract   
  Molecular Pathology 2020: Antiparkinsonian potential of certain quinolone derivatives: insights into Nurr-1 and autophagy roles - Shireen A. Hedya - Cairo University
  Author(s): Shireen A. Hedya
  
  Nuclear receptor related-1 (Nurr1) orphan receptor has emerged as a promising contender in ameliorating Parkinson’s disease, thus finding a suitable activator of Nurr1 receptor is an attracting target for treating PD. Meanwhile, the deregulation of autophagy, along with other processes such as; inflammation, apoptosis and mitochondrial dysfunction is believed to contribute to the pathogenesis of the disease. The aim of this study is to explore the neuroprotective effect of cilostazol and hydroxychloroquine in rotenone-induced PD model in rats. Both drugs managed to enhance the dopaminergic neurons functionality and integrity as depicted by the increase in the striatal tyrosine hydroxylase content, as well as the i.. Read More»
  

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