Cardiovascular Diseases & Diagnosis

Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University, India

Publications

• Review Article   
  Relation between Mitochondrial Dysfunction and Cardiovascular Disease
  Author(s): Shivangi Chauhan*
  
  Globally, cardiovascular disease (CVD) is considered to be an important cause of mortality. The proper functioning of mitochondria is essential in tissues and organs which require high energy, involving the heart. Mitochondria are extremely sensitive towards nutrient and oxygen supply and experience metabolic adaptation due to the change in environment. Such adaptation is damaged in CVD that sequentially results in the degeneration of mitochondrial function correlated with irregularities in the respiratory chain and ATP production, raised oxidative stress, and loss of the structural integrity of mitochondria. Uncoupling of the respiratory chain in dysfunctional mitochondria leads to higher production of reactive oxygen species(ROS), reduction of cell ATP pool, massive cell damage, and apoptosis of cardiomyocytes. In a mitophagy process, cells clear themselves from im.. Read More»
  DOI: 10.37421/2329-9517.2021.9.459

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