Molecular Biology: Open Access

Department of Biotechnology and Bioinformatics, Jawaharlal Nehru Tropical Botanical Garden and Research Institute, Thiruvanathapuram, Kerala, India

Publications

• Research Article   
  A Computational Approach towards Targeting Parkinson’s Disease: The Discovery of Potential Inhibitors against Alpha-Synuclein and Pten-Induced Putative Kinase 1 Protein
  Author(s): Suganya Selvaraj*, Shobana Sundar and Shanmughavel Piramanayagam
  
  Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease caused by the degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc), which influences the basal ganglia network that results in a host of the motor and cognitive deficits. The autosomal dominant and recessive form of Parkinson’s disease caused by the abnormal aggregation of Alpha-synuclein and PTEN- induced putative kinase 1 protein. The present study focuses on developing lead compounds and antibody mimetic oligopeptides for inhibiting PD targets such as SNCA and PINK1. Virtual screening and docking were performed to find the best lead compounds further the docked complex were subjected to a molecular dynamics approach to predict the stability and the lowest conformation energy of the compounds. Nearly 5780 Similar compounds of carbidopa.. Read More»
  DOI: 10.37421/2168-9547.2021.10.278

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