Journal of Antimicrobial Agents

Department of Pharmaceutical Chemistry, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, India

Publications

• Review Article   
  Solid Phase Peptide Synthesis and Its Applications in Tackling Antimicrobial Resistance
  Author(s): Aditya Prakash Sarode* and Shraddha Dingare
  
  Solid Phase Peptide Synthesis (SPPS) is a powerful tool for the design and synthesis of peptides with potential antimicrobial activity. In recent years, SPPS has emerged as a promising strategy for the development of new antimicrobial agents. SPPS is a synthetic method that allows for the efficient and rapid production of peptides using solid-phase supports. This technique involves stepwise addition of protected amino acids to a resin-bound peptide chain, followed by deprotection and cleavage to release the desired peptide. The resulting peptides can be modified to enhance their activity, stability, and bioavailability. One of the key advantages of SPPS is its ability to produce peptides with high purity and homogeneity. This is critical for the development of antimicrobial peptides, which require high levels of activity and specificity to target bacterial cells effectively. Additiona.. Read More»
  DOI: 10.37421/2472-1212.2023.9.320

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