Stanley Dobgima Gamua

Laboratory for Drugs and Molecular Diagnostics Research (ANDI Centre of Excellence for Onchocerciasis Drug Research), Biotechnology Unit, University of Buea, Buea, Cameroon

Publications

Research Article
In Vitro Anti-onchocercal Activity, Phytochemical Analysis and Toxicity Studies of Extracts of Azadirachta indica
Author(s): Irene Memeh Tumanjong, Tobias Obejum Apinjoh, Faustin Pascal Tsague Manfo, Evans Ngandung Mainsah, Stanley Dobgima Gamua and Fidelis Cho-Ngwa*

Ivermectin and moxidectin are the only recommended drugs for the treatment of onchocerciasis, with the former being the most widely used. However, both drugs are not suitable in eliminating the disease. There is the need to identify novel anti-onchocercal agents including from plant sources. This project investigated the anti-onchocercal activity of extracts of Azadirachta indica that could eventually yield new drug leads for the cure of onchocerciasis. Organic extracts were obtained from the leaves and seeds of Azadirachta indica using solvents of different polarities and tested in vitro against two developmental stages of the bovine model parasite, Onchocerca ochengi. Both microfilariae (mf) and adult male worm viabilities were assessed by motility reduction, while adult female worm viability was evaluated using the standard MT.. Read More»
DOI: 10.37421/2472-0992.2024.10.281

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