Journal of Computer Science & Systems Biology

Department of Pharmacognosy, Obafemi Awolowo University, Ile Ife, Nigeria

Publications

• Research Article   
  Involvement of Cissus populnea Derived Compounds in Phosphodiesterase Pathway in Erectile Dysfunction: In Silico Study
  Author(s): Moses Orimoloye Akinjiyan*, Olusola Olalekan Elekofehinti, Ayomide Precious Ajiboro, Elizabeth Foluke Awodire, Adeodotun Olayemi Oluwatuyi and Stephen Adeleke Adesida
  
  Erectile Dysfunction (ED) has been a threat among couples and is one of the challenging disorders in Nigeria and the world. Various drugs targeting Phosphodiesterase 5 (PDE5) inhibition like Pyrazinopyridoindole (Tadalafil), have been used for the treatment of ED but, they are associated with side effects such as headache, diarrhea, back pain, and stomach upset among others. Medicinal plants are now being explored for the treatment of various diseases and disorders including ED because they are affordable with little or no side effects. Cissus populnea (CP) is a popular plant in Nigeria used in the management of ED but there is a paucity of information on the mechanisms involved. In this study, Schrodinger suites were employed for docking of thirty-eight CP phytocompounds gotten from HPLC analysis and works of literature against Phosphodiesterase PDE5, a key enzyme in the ere.. Read More»
  DOI: 10.37421/0974-7230.2022.15.432

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