Journal of Metabolic Syndrome

Department of Physiology, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Publications

• Review Article   
  Trimethylamine-N-Oxide (TMAO): Potential Benefits, and Therapeutic Targets Conceivable as a Mitigation Strategy for Cardio-Metabolic Diseases
  Author(s): Oscar Mbembela*, Tuntufyege Mwasanjobe, Anselmo M Manisha, Suzan Kilamile, Hamad S Ali, Jacktan Josephat Ruhighira and Frederick Mashili
  
  Trimethylamine-N-oxide (TMAO) is the gut microbiome derived metabolite synthesized from a volatile amine-containing organic compound called Trimethylamine (TMA) by the action of the hepatic Flavin Monooxygenase enzyme (FMO) isoform 1 and 3. TMA is largely synthesized from choline, betaine and L-carnitine by gut microbial enzymes. TMAO has been speculated to be independently associated with various cardiometabolic and chronic diseases in humans such as atherosclerosis, type 2 diabetes mellitus, cancers, Chronic Kidney Disease (CKD), heart failure and dyslipidemia. In marine animals, TMAO has been purported to be useful in counteracting the effect of osmotic stress and hydrostatic pressure emanating from their surrounding environment. In this review, the potential benefits and comparable deleterious effect of TMAO in animals and human has been elucidated. The interventions targeting TMA.. Read More»
  DOI: 10.37421/ 2167-0943.2023.12.319

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