Journal of Blood & Lymph

Department of Molecular Pathology, The Aga Khan University Hospital, National Stadium Road, Karachi, Sindh, 74800, Pakistan

Publications

• Research Article   
  Molecular Epidemiology of BCR-ABL Rearrangement Variants in Chronic Myeloid Leukemia and Acute Lymphocytic Leukemia from Major Institute of Pakista
  Author(s): Zeeshan Ansar Ahmed, Muhammad Shariq Shaikh, Muhmmad Hasan Hayat, Hamayail Ansari, Huzaifa Bin Rashid, Tariq Moatter and Zeeshan Ansar Ahmed*
  
  In Pakistan the disease burden of Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL) is quite high, yet there is a lack of scientific evidence regarding the spectrum of BCR-ABL rearrangement variants in CML and ALL. Knowing about BCR-ABL rearrangement is important in determining the prognosis and treatment strategy of disease at the time of diagnosis. This study included a total of 685 patients, out of which there were 644 CML patients and 41 ALL patients, from October 2016-July 2019. From the CML group, 270 patients were reported to have the BCR-ABL1 transcript, from which 50% were males. Whereas in the ALL group, 35 patients were reported to have the BCR-ABL1 transcript out of which 65.7% were males. Proportions of BCR-ABL transcript type differed between the two groups, with b3a2 (63.3%) and b2a2 (34.8%) transcript types having the highest frequency in CML patien.. Read More»
  DOI: 10.37421/2165-7831.2021.11.261

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