Molecular and Genetic Medicine

Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Portugal

Publications

• Commentary   
  Post-operative Atrial Fibrillation at the Start of Atrial Fibrillation Burden
  Author(s): Fragão-Marques M*, Teixeira F, Falcão-Pires I and Leite-Moreira A
  
  Atrial Fibrillation (AF) is the most common persistent arrhythmia with adverse clinical outcomes. AF ectopic firing and re-entry depends on several mechanisms: (1) ion channel dysfunction; (2) Ca2+-handling abnormalities; (3) structural remodelling; (4) autonomic neural dysregulation. The oxidized CAMKII enzyme pathway establishes a connexion between redox imbalance and the electrical and functional cardiomyocyte properties altered in AF patients. Postoperative atrial fibrillation (PoAF) is the most common complication after cardiac surgery and a subtype of AF, associated with increased time spent in the intensive care unit (ICU), in-hospital stay, stroke incidence and 30-day and long-term mortality. Recent studies have implicated oxidative stress in AF pathophysiology including mechanisms such as an imbalance in reactive oxygen species (ROS) production,.. Read More»
  DOI: 10.37421/1747-0862.2021.15.496

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