Cancer Science & Therapy

Department of Surgery, Division of Pediatric Surgery, Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 60611, USA

Publications

• Research Article   
  HDAC-6 Regulation of HIF-1α Plays an Important Role in Mediating both Drug Resistance and Invasiveness in Osteosarcoma and Breast Cancer Cells
  Author(s): Fei Chu*, Nicholas J. Skertich, Timothy B. Lautz, Stephen Szajek and Mary Beth Madonna*
  
  Objective: Despite advances in cancer treatment, chemotherapy resistance and metastasis are major hurdles in curative cancer treatment. Studies involving drug resistance and cancer metastasis have generally proceeded along separate pathways of research. Current interest has focused on a possible relationship between drug resistance and cancer metastasis, since the molecular basis for drug resistance with an aggressive metastatic phenotype remains to be elucidated. We aim to show that histone deacetylase (HDAC) involvement in hypoxia-inducible factor-1α (HIF-1α) regulation may connect drug resistance to cancer invasiveness in osteosarcoma and breast cancer. Methods: We created a doxorubicin resistant (DoxR) cell line from wildtype (WT) human osteosarcoma (SJSA-1) and breast cancer (MCF-7) cells. Matrigel in v.. Read More»
  DOI: 10.37421/1948-5956.22.14.519

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