Immunochemistry & Immunopathology

Department of Immunology, Kindai University, Wakayama 649-6493, Japan

Publications

• Mini Review   
  Decoding Cross-presentation: Unravelling MHC-mediated Molecular Functions and Regulatory Mechanisms
  Author(s): Tindea Mechteleria*
  
  Cross-presentation, a fundamental process in immunology, plays a pivotal role in the adaptive immune response by presenting extracellular antigens on Major Histocompatibility Complex Class I (MHC-I) molecules. This comprehensive review delves into the intricate molecular characteristics, functional definitions and regulatory mechanisms governing cross-presentation. The exploration encompasses the diverse cellular players involved in this process, emphasizing the central role of antigen-presenting cells, particularly dendritic cells. The review outlines the molecular machinery responsible for the generation of MHC-I/peptide complexes from exogenous antigens, shedding light on the precise mechanisms that orchestrate cross-presentation. Furthermore, the regulatory checkpoints governing the efficiency and specificity of cross-presentation are dissected, providing i.. Read More»
  DOI: 10.37421/2469-9756.2023.9.212

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