Neurological Disorders

Department of Cellular and Molecular Medicine, University of Ottawa, Canada

Publications

• Research   
  Dysregulation of Insulin Signaling in Human AD Brain and Alleviation of A?-Induced Insulin Resistance by Amyloid-? Binding Peptide (ABP) in Neural Cells
  Author(s): Yuka Sai, Balu Chakravarthy, Debbie Callaghan, Qiao Li and Wandong Zhang*
  
  Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of extracellular amyloid-β peptides (Aβ) and intraneuronal neuro-fibribillary tangles in the brain. Increasing evidence builds a strong case for the role of soluble Aβ oligomers (AβOs) in the impairment of insulin signaling in AD. Insulin signaling pathway begins upstream at the insulin receptor by phosphorylating IRS1 and propagating the signal downstream to the PI3K/ Akt which down-regulates GSK3β activity for tau phosphorylation and activates mTORC1 that mediates a wide range of cellular functions. Our study found that human AD brains had high levels of Aβ peptides with cerebral amyloid angiopathy (AD/CAA) and showed low activities of insulin signaling-responsive transcription factors as compared to age-matched non-demented controls (ND). Our fu.. Read More»
  DOI: 10.4172/2329-6895.11.3.552

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