Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA
Research Article
Highly Variable Expression of ESR1 Splice Variants in Human Liver: Implication in the Liver Gene Expression Regulation and Inter-Person Variability in Drug Metabolism and Liver Related Diseases
Author(s): Sun JW, Collins JM, Ling D and Wang D*
Estrogen receptor alpha (ESR1) plays an important role in many tissues including the liver. Numerous alternative
splice variants of ESR1 exist that encode ESR1 proteins with varying functions. We aim to study ESR1 genomic
organization and its mRNA expression profile in human liver by incorporating information from literature and genomic
databases (Ensembl, NCBI and GTEx), and employing a quantitative method to measure all known ESR1 mRNA
splice variants in 36 human livers. We re-constructed ESR1 genomic organization map that contains 29 exons.
ESR1 mRNA splice variants with varying 5’ untranslated region (5’UTR) and/or missing each of eight coding exons
are readily detectable in liver and other tissues. Moreover, we found extensive inter-individual variability in splice
variant pattern of .. Read More»
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