Journal of Infectious Diseases and Medicine

Department of Infectious Disease Research, George Mason University, Manassas, VA 20110, USA

Publications

• Mini Review   
  Using Small Interfering RNAs, the Venezuelan Equine Encephalitis Virus is Inhibited
  Author(s): Weidong Boghdeh*
  
  Due to a lack of efficient therapeutic intervention options, acutely contagious new world alphaviruses like the Venezuelan Equine Encephalitis Virus (VEEV) pose significant risks to the human population. Several in vitro and in vivo models of acute viral infections, including those involving alphaviruses like the Chikungunya virus and filoviruses like the Ebola virus, have shown that small interfering RNAs (vsiRNAs) that can specifically target the viral genome provide survival advantages. In this study, novel vsiRNAs were created and tested for antiviral efficacy in mammalian cells during VEEV infection. These vsiRNAs targeted conserved areas in the nonstructural and structural genes of the VEEV genome. The results show that vsiRNAs could successfully lower the infectious virus titer at earlier stages after infection. The inhibition was overcome at subsequent time.. Read More»
  DOI: 10.37421/2576-1420.2022.7.255

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