Journal of Infectious Diseases and Medicine

Department of Infectious Disease Research, George Mason University, Manassas, VA 20110, USA

Publications

• Mini Review   
  Small Interfering RNAs are Being used to keep the Venezuelan Equine Encephalitis Virus
  Author(s): Weidong Boghdeh*
  
  Due to a lack of effective remedial intervention options, acutely contagious new world alphaviruses like the Venezuelan Equine Encephalitis Virus (VEEV) pose significant pitfalls to the mortal population. Several in vitro and in vivo models of acute viral infections, including those involving alphaviruses like the Chikungunya contagion and filoviruses like the Ebola contagion, have shown that small snooping RNAs (vsiRNAs) that can specifically target the viral genome give survival advantages. In this study, new vsiRNAs were created and tested for antiviral efficacity in mammalian cells during VEEV infection. These vsiRNAs targeted conserved areas in the nonstructural and structural genes of the VEEV genome. The results show that vsiRNAs could successfully lower the contagious contagion titer at earlier stages after infection. The inhibition was overcome at post.. Read More»
  DOI: 10.37421/2576-1420.2022.7.263

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