Department of Chemistry, Tianjin University, Tianjin, China
Short Communication
Retrosynthetic Analysis: Planning the Route to Drug Synthesis
Author(s): Weingart Houdeau*
The process of drug synthesis is a complex and intricate task that involves the transformation of raw chemical materials into a therapeutic
compound with specific biological activities. One of the key strategies employed in the design and synthesis of pharmaceuticals is retrosynthetic
analysis. This powerful method, pioneered by Nobel laureate Elias James Corey, allows chemists to deconstruct a target molecule into simpler
precursor molecules, ultimately guiding the synthesis backward from the final product to readily available starting materials. Retrosynthetic analysis
is an indispensable tool in the field of organic chemistry, providing a systematic approach to planning the most efficient and feasible route for
drug synthesis. Retrosynthetic analysis relies on the identification of key functional groups and strategic disconnections within a target molecule.
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DOI:
10.37421/2150-3494.2023.14.383
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