Journal of AIDS & Clinical Research

Center of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, P.R. China

Publications

• Research Article   
  Tenofovir Disoproxil Fumarate-Lowering Lipid Effects Moderately Protect Liver during Long-Term Antiretroviral Therapy in HIV-Infected Patients
  Author(s): Lijuan Ouyang, Zhong Si Hong, Wen Xiao Dong, Hong Qiong Zhu, Ying Li and Xiao Mou Peng*
  
  Background: Non-alcoholic fatty liver disease is prevalent in HIV-infected patients and dyslipidemia is the main cause of long-term toxicities of current antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is a commonest antiretroviral of ART. It has been reported to have lipidlowering effects. Objectives: In this study, the influences of the lipid-lowering effects of TDF on fatty liver, liver function profiles and renal toxicity were further investigated in mono-HIV-infected patients during long-term ART up to five years. Methods: 115 and 38 HIV-infected, ART-naive patients who respectively received TDF- and zidovudine (AZT)-based regimens for 5 years were enrolled. The differences in lipid profiles, liver functions and renal toxicity between those two groups of patients and the correlati.. Read More»
  

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