Journal of Lung Diseases & Treatment

Department of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China

Publications

• Mini Review   
  Alveolar Macrophage Propagation is Controlled by Several Neutrophil Death Alleyway
  Author(s): Xiaochen Zhang*
  
  The proliferation and self-renewal of alveolar macrophages (AM) are significant components of the microenvironment of lung tissue. The effect of immune cells, particularly neutrophils, on the homeostasis or functionality of AM is not fully understood. In this investigation, we used CXCL1 to promote neutrophil in vivo migration into bronchoalveolar lavage (BAL) fluid and lung, and we co-cultured these cells with AMs in vitro. It was discovered that BAL neutrophils (BAL-neutrophils) as opposed to BM-neutrophils limit AM growth. An analysis of data that was made accessible to the public revealed that there was significant molecular heterogeneity between blood and BM neutrophils and lung neutrophils. Unexpectedly, BAL-neutrophils from mice infected with the influenza virus PR8 (PR8-neutrophils) did not prevent the growth of AMs. Additionally, bulk RNA sequencing de.. Read More»
  DOI: 10.37421/2472-1018.2022.8.161

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