Biosensors & Bioelectronics

Department of Regenerative Medicine, Shenyang Jianzhu University, Shenyang 110168, China

Publications

• Mini Review   
  Accelerating Maturation of Human iPSC-Derived Dopamine Neurons with Organ-Chip Technology
  Author(s): Yang Woo*
  
  The maturation of human-induced Pluripotent Stem Cell (iPSC)-derived dopamine neurons holds great promise for disease modeling and drug discovery in neurodegenerative disorders like Parkinson's disease. However, achieving the appropriate maturation state remains a significant challenge. This study explores the application of Organ-chip technology to accelerate the maturation of iPSC-derived dopamine neurons. Organchips provide a microfluidic environment that mimics in vivo conditions, allowing for precise control of biochemical and biophysical cues. By culturing iPSC-derived dopamine neurons within Organ-chips, we observe enhanced maturation, including increased neuronal complexity, functional properties and maturity markers. These findings offer a novel approach to advancing the development of more physiologically relevant in vitro models for neu.. Read More»
  DOI: 10.37421/2155-6210.2023.14.410

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