Journal of Infectious Diseases and Medicine

Department of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China

Publications

• Perspective   
  Acinus Allergen 2 Insufficiency Persuade Nimble Responses and Regulate Rapacious Deltacoronavirus Infection
  Author(s): Yang Zhang*
  
  Porcine deltacoronavirus (PDCoV) is a lately observed enteropathogenic coronavirus and has prompted substantial monetary influences on the pork industry. Although research has partly uncovered the molecular mechanism of PDCoV–host interaction, it requires in addition research. In this study, we explored the roles of Stromal Antigen two (STAG2) in PDCoV infection. We located that STAG2-deficient cells inhibited contamination with vesicular stomatitis virus (VSV) and PDCoV, whereas restoration of STAG2 expression in STAG2-depleted (STAG2−/−) IPEC-J2 cells line restored PDCoV infection, suggesting that STAG2 is concerned in the PDCoV replication. Furthermore, we located that STAG2 deficiency consequences in strong interferon (IFN) expression. Subsequently, we observed that STAG2 deficiency outcomes in the activation of JAK-STAT signaling and the .. Read More»
  DOI: 10.37421/2576-1420.2022.7.239

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