Ying Liu

Department of Key Laboratory of Power Station Energy Transfer Conversion and System, Ministry of Education, North China Electric Power University, Beijing, 102206, P.R. China

Publications

Research Article
Treatment of Liver Cancer Using Specifically Targeted PLGAbased Paclitaxel Nanoparticle
Author(s): Ying Liu*

We have designed a nanoparticle drug delivery system. The system included PLGA, paclitaxel (PTX) and transferrin (TF). This system can specifically target to liver cancer cells through intravenously administration. The PLGA-PTX-TF nanoparticles show excellent liver cancer treatment effect (IC50 4.79 g/mL) and are dose dependent in vitro. The PLGA-PTX-TF nanoparticle also show noticeable anti-tumor efficacy in vivo compared to PLGA-PTX (anti-cancer rate: 79.09% vs. 35.47%). Therefore, PLGA-PTX-TF nanoparticles can be considered as an effective anticancer drug delivery system for liver cancer therapy for the clinical use... Read More»

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