Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Japan
Review Article
TSEC (Tissue Selective Estrogens Complex) for Women with Postmenopausal Symptoms
Author(s): Ikuko Ota*, Yoshiaki Ota and Fuminori Taniguchi
The hormonal changes associated with menopause accounts for an unpleasant menopause symptom and a rapid decrease in bone mineral density. The former significantly impairs
women's quality of life, and the latter causes locomotor disorders as well as osteoporosis in old age. Estrogen-Progestin Therapy (EPT) is useful for reducing menopausal symptoms
(vasomotor symptoms (VMS) and vulvar/vaginal atrophy (VVA)) in postmenopausal women, and for preventing osteoporosis. However, EPT has the concerns about adverse effects
on the breast, and endometrium such as Abnormal Uterine Bleeding (AUB). The Tissue Selective Estrogen Complex (TSEC) has improved safety and tolerability by combining the
Selective Estrogen Receptor Modulators (SERMs), which have an estrogen agonist/antagonist effect on tissue selectivity, with estrogen. Bazedoxifene (BAZ), which has the strongest
antagonistic.. Read More»
DOI:
10.37421/2795-6172.2021.5.135
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