Journal of Clinical Research

Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Japan

Publications

• Review Article   
  TSEC (Tissue Selective Estrogens Complex) for Women with Postmenopausal Symptoms
  Author(s): Ikuko Ota*, Yoshiaki Ota and Fuminori Taniguchi
  
  The hormonal changes associated with menopause accounts for an unpleasant menopause symptom and a rapid decrease in bone mineral density. The former significantly impairs women's quality of life, and the latter causes locomotor disorders as well as osteoporosis in old age. Estrogen-Progestin Therapy (EPT) is useful for reducing menopausal symptoms (vasomotor symptoms (VMS) and vulvar/vaginal atrophy (VVA)) in postmenopausal women, and for preventing osteoporosis. However, EPT has the concerns about adverse effects on the breast, and endometrium such as Abnormal Uterine Bleeding (AUB). The Tissue Selective Estrogen Complex (TSEC) has improved safety and tolerability by combining the Selective Estrogen Receptor Modulators (SERMs), which have an estrogen agonist/antagonist effect on tissue selectivity, with estrogen. Bazedoxifene (BAZ), which has the strongest antagonistic.. Read More»
  DOI: 10.37421/2795-6172.2021.5.135

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