Reports in Thyroid Research

Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

Publications

• Mini Review   
  Therapeutic Potential of Liver X Receptors: Targeting Lipid Disorders and Beyond
  Author(s): Zenifer Zolia*
  
  Liver X Receptors (LXRs) are nuclear hormone receptors with a pivotal role in lipid metabolism regulation. LXRs, specifically LXRα and LXR , control cholesterol homeostasis, dyslipidemia, and atherosclerosis, making them attractive therapeutic targets for lipid disorders. Synthetic LXR agonists and Selective LXR Modulators (SLiMs) have been developed, showing promise in preclinical models, although side effects remain a concern. Additionally, LXRs are emerging as therapeutic candidates beyond lipid disorders. They may influence neurodegenerative diseases by modulating inflammation and amyloid-beta metabolism and impact cancer and metabolic disorders through cell proliferation and glucose metabolism regulation. Challenges include mitigating side effects, achieving tissue-specific targeting, and conducting robust clinical trials. In conclusion, LXRs hold vast therapeutic potential.. Read More»
  DOI: 10.37421/2684-4273.2023.7.41

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