Epilepsy Journal

Department of Pediatric Orthopedic Surgery, Lille University Centre, Lille, France

Publications

• Brief Report   
  Uncovering the Relationship between Gut Microbiota, Neurophysiological States and Bone Diseases
  Author(s): Zhiyang Yufan*
  
  Elevating evidence underscores a strong connection between gut microbiota and bone diseases, yet the presence of a definitive causal link between them remains elusive. In this investigation, we conducted a comprehensive examination of the association between gut microbiota and skeletal disorders utilizing genome-wide association studies. We employed linkage disequilibrium score regression and Mendelian randomization to delve into genetic causation. Additionally, we explored the possible intermediary role of neuropsychological states, such as cognition, depression, and insomnia, in the relationship between gut microbiota and bone diseases through mediation analysis. Genetic colocalization analysis was employed to identify potential targets. Our findings point to a direct causal connection between Ruminococcaceae and knee Osteoarthritis (OA), with this association seemingly influenced b.. Read More»
  DOI: 10.37421/2472-0895.2023.9.196

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