Department of Infectious Diseases, University of Queensland, Brisbane, QLD 4072, Australia
Mini Review
Exploring SARS-CoV-2 Neutralization Assays in Clinical Trials: A Comprehensive Narrative Review
Author(s): Ziyao Zhao*
The emergence of SARS-CoV-2 has spurred global efforts to develop effective vaccines and therapeutics to combat COVID-19. Critical to this
endeavor is the evaluation of interventions' ability to neutralize the virus, a task accomplished through neutralization assays. This narrative
review examines the diverse neutralization assays utilized in clinical trials targeting SARS-CoV-2. These assays, ranging from plaque reduction
to pseudovirus and live virus assays, offer distinct advantages and considerations in terms of safety, sensitivity, and scalability. Employed in trials
assessing vaccines, monoclonal antibodies, convalescent plasma, and antiviral drugs, neutralization assays provide crucial data on interventions'
ability to induce neutralizing immunity, guide dose selection, assess treatment efficacy, and inform regulatory decisions. Despite their utility,
ch.. Read More»
DOI:
10.37421/2795- 6172.2024.8.241
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