DOI: 10.37421/1948-593X.2022.14.314
The M-band and Z-disc are transversal structural features of cross-striated muscles that anchor and mechanically support the contractile apparatus and its minimum unit, the sarcomere. Proteins' capacity to locate and interact with these structural sarcomeric parts is an unavoidable requirement for proper myofbrillar apparatus construction and function. The M-band, in particular, is a well-known mechanical and signalling hub that deals with active forces during contraction, and its damage causes sickness and death. The assembly and interactions of the three key flamentous proteins in the region, primarily the three myomesin proteins, including their Embryonic Heart (EH) isoform, titin, and obscurin, are the focus of research on the M-band architecture.
Maria Sherry and Lewis Nixon*
DOI: 10.37421/1948-593X.2022.14.315
Extracellular vesicles can be released by any cell, including prokaryotes and eukaryotes (EVs). EVs are vital for maintaining appropriate intercellular communication and internal environment balance because they include various cellular components such as RNA and surface proteins. EVs released from various tissues and cells have a wide range of features and functions (e.g., targeted specificity, regulatory ability, physical durability, and immunogenicity), making them a promising novel drug delivery and precision therapy alternative. The ability of EVs to transport anticancer medications for tumour therapy has been proven; additionally, the contents and surface material of EVs can be adjusted to improve their therapeutic efficacy in the clinic by increasing targeting potential and drug delivery effectiveness. By affecting the tumour microenvironment, EVs can control immune system function and hence slow tumour development.
DOI: 10.37421/1948-593X.2022.14.316
Himansh Priyadarshan and Saransh Priyadarshan*
DOI: 10.37421/1948-593X.2022.14.317
Himansh Priyadarshan and Saransh Priyadarshan*
DOI: 10.37421/1948-593X.2022.14.318
DOI: 10.37421/1948-593X.2022.14.319
DOI: 10.37421/1948-593X.2022.14.320
DOI: 10.37421/1948-593X.2022.14.321
DOI: 10.37421/1948-593X.2022.14.322
DOI: 10.37421/1948-593X.2022.14.323
DOI: 10.37421/1948-593X.2022.14.348
Radiological and Atomic (CBRN) danger, because of its extraordinary geographic position. Natural danger is an unavoidable danger in the possession of a fear monger. The general wellbeing arrangement of our nation is overburdened because of its current job and bio-assault reaction isn't fundamentally important region. This paper recommends that as the great spotlight is on the CR and N dangers in the coordinated CBRN readiness methodology and that specific and specialized powers are expected to manage a bio-danger; subsequently there is a requirement for a change in perspective in strategy. The arising field of bio-danger should be delinked from the joint group of 'CBRN', with ensuing primary and practical changes. A different specific framework should be shaped for managing bio-danger, made from the pool of specialists and non-clinical researchers from the AFMS and the DRDO. Underlying changes are required in the association, to get the assets of NCDC, New Delhi for improved illness observation limit and production of a bio-danger moderation hub in the AFMC, Pune.
DOI: 10.37421/1948-593X.2022.14.347
We want to talk about bionanoparticles, which have the unique properties of being self-assembling and multifunctional. In particular, protein cages like those found in plant viruses and ferritin, in addition to other clearly defined self-assembling structural motifs of proteins, are useful building blocks with a lot of potential in (bio) nanotechnology. Biomedicine, diagnostics and analytics, and nanoelectronics are just a few of the fields in which promising results and applications are being presented by a growing number of research projects. Bionanoparticles for hybrid and soft protein–polymer composite materials, on the other hand, have not yet received a lot of attention. The structure of a few selected plant viruses and ferritin will be used as an example to illustrate the structural principles of clearly defined protein complexes in the beginning of the article. The use of modified bionanoparticles in the production of novel nanostructured (hybrid) materials and recent advances in chemical or genetically programmed functionalization will then be discussed. Additionally, an up-to-date overview of grafting-onto and grafting-from polymerization strategies for protein and protein complex modification will be provided. The article comes to a close with some fascinating examples of how bio (in-) organic nanoparticles are used in biomedical applications, catalysis, and analytics.
DOI: 10.37421/1948-593X.2022.14.346
DOI: 10.37421/1948-593X.2022.14.345
DOI: 10.37421/1948-593X.2022.14.344
Journal of Bioanalysis & Biomedicine received 3099 citations as per Google Scholar report
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