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Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Articles in press and Articles in process

    Commentary Pages: 1 - 2

    Which Human Leukocyte Antigen (HLA) are Donor-Derived T-cells Restricted to After HLA-Mismatched Hematopoietic Stem Cell Transplantation?

    Kazuhiro Ikegame*

    With advances in preconditioning regimens and supportive care, transplants from related donors who share only one of the two Human Leukocyte Antigen (HLA) haplotypes known as HLA. Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HCT) have been widely performed. Three HLA haplotypes are involved in haplo-HCT: The shared haplotype of the patient and donor (shared HLA), the haplotype uniquely possessed by the donor (donor-specific HLA) and the haplotype belonging to the patient (host-specific HLA). In this context, a critical question arises: Which HLA are donor-derived T cells restricted to after transplantation? Immediately following transplantation, mature donor T and stem cells are transferred to the recipient’s body.

    Mini Review Pages: 1 - 5

    Review of Proliferative Retinopathy in Chronic Myeloid Leukemia (CML)

    Alan Chew Bonilla*, Emanuel Chew Bonilla, Paulina Bueno Zarazua and Federico Graue Wiechersa

    Proliferative retinopathy is a significant ocular complication associated with Chronic Myeloid Leukemia (CML) and other forms of leukemia. Understanding the various ophthalmological manifestations and their management is important for improving patient outcomes. This review aims to provide a comprehensive overview of the ocular alterations seen in leukemia patients, with a particular focus on proliferative retinopathy in CML, its delayed manifestation and management strategies. A thorough literature review was conducted, emphasizing key studies and case reports that highlight the ocular complications of leukemia, particularly those related to proliferative retinopathy in CML. Leukemia can cause a range of ophthalmic manifestations, including retinal hemorrhages, microaneurysms and neovascularization. Proliferative retinopathy, characterized by abnormal neovascularization is more common in chronic leukemias like CML. This condition often presents in the advanced stages of CML and can significantly impair vision if not managed promptly. The pathogenesis involves chronic hypoxia, leukostasis and inflammatory mediators, leading to the formation of fragile new blood vessels. Delayed manifestation of proliferative retinopathy in CML underscores the importance of regular ophthalmological surveillance, even in patients with well-controlled systemic disease. Early detection and timely intervention are essential in managing proliferative retinopathy in CML. A multidisciplinary approach involving both hematologists and ophthalmologists is essential for optimal patient care. Regular follow-up and vigilant screening for ocular changes can significantly improve the prognosis and quality of life for leukemia patients. This review highlights the need for ongoing research and education to better understand and manage the ocular complications of leukemia.

      Editorial Pages: 1 - 1

      Pharmacokinetic Properties of Anticancer Medications in Chemotherapy

      Melisyah Meliana

      Pharmacokinetics is the investigation of digestion of medications in organic liquids, tissues and excreta. The discoveries of ongoing improvements uncover that Multidrug Obstruction (MDR) adjusted the bioavailability of orally managed drugs through enlistment or restraint. Part of Multi-drug treatment: MDR is a term used to portray the marvel described by the capacity of medication safe tumors to display synchronous protection from various primarily and practically disconnected chemotherapeutic specialists. Various systems have been portrayed to clarify the wonder of MDR in mammalian cells. They have been extensively ordered into cell and non-cell components. Boundaries of pharmacokinetic inconstancy in malignancy patients:

      Commentary Pages: 1 - 1

      Compensatory Rehabilitation in the Complete 10,11,12 Thoracic level injury

      Jeena Aniston

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      Road traffic accidents are increasing day by day which will result in Spinal cord Injury to the victims. In Spinal cord Injury nervous system is affected which is not re-gene ratable so whatever damage occur its permanent for rest of life. Thoracic spinal cord injury patient have spared Upper extremities and some trunk muscle with use of those and some assistive devices patient can achieve the independence in his life

        Commentry Pages: 1 - 2

        Vitamin B12 deficiency anemia is pernicious anemia

        Bunkechukwu Mehemed

        Frailty with bone marrow promegaloblastosis (megaloblastic weakness). This is because of the restraint of DNA blend (explicitly purines and thymidine). Gastrointestinal side effects: modification in inside motility, like gentle the runs or blockage, and loss of bladder or gut control. These are believed to be because of flawed DNA amalgamation repressing replication in tissue destinations with a high turnover of cells. This may likewise be because of the immune system assault on the parietal cells of the stomach in noxious paleness. There is a relationship with gastric antral vascular ectasia (which can be alluded to as watermelon stomach), and malicious anemia. Neurological manifestations: tangible or engine insufficiencies (missing reflexes, lessened vibration or delicate touch sensation) and sub acute consolidated degeneration of the spinal cord. Deficiency side effects in kids incorporate formative postponement, relapse, peevishness, compulsory developments and hypotonia.

Google Scholar citation report
Citations: 443

Journal of Blood & Lymph received 443 citations as per Google Scholar report

Journal of Blood & Lymph peer review process verified at publons

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