Bayarak Elesin
Cancer is a highly complex and heterogeneous disease, where the
genetic landscape and cellular makeup of tumors exhibit vast variation not only
between patients but also within a single tumor. This heterogeneity contributes
to challenges in diagnosis, treatment response, and the development of
therapeutic resistance. Traditional bulk genomic sequencing approaches, which
analyze average gene expression or mutation profiles from a large collection of
cells, often fail to capture the diversity of the Tumor Microenvironment (TME) or
reflect the interactions between different cell populations within a tumor.
Lyon Mangos
Cancer remains one of the leading causes of death globally, with over
18 million new cases and 9.6 million deaths reported annually. Despite the
progress made in understanding its molecular and genetic underpinnings,
effective treatment remains a challenge due to the inherent complexity
and heterogeneity of the disease. The advent of cancer genomics has
revolutionized cancer research and clinical practice by providing insights into
the genetic mutations, alterations, and pathways that drive tumorigenesis and
disease progression. However, while genomic data has the potential to offer
personalized therapeutic strategies, the sheer volume and complexity of this
information present significant challenges in its interpretation and application.
Kishani Elanie
Consanguinity, defined as marriage or reproduction between individuals
who share a common ancestor, is common in many cultures around the
world. In certain regions, consanguineous unions are deeply embedded in
social, religious, and cultural practices, and they may serve purposes such
as preserving family wealth, consolidating power, or maintaining lineage
continuity. However, consanguinity has important implications for reproductive
health, particularly when it comes to the genetic risks posed by inbreeding.
Loran Pinara
Consanguinity, or marriage between individuals who share a common
ancestor, has been practiced across various cultures and regions of the
world for centuries. Historically, consanguineous unions were encouraged for
reasons related to social cohesion, economic gain, or maintaining the purity of
lineage and family ties. In many parts of the world, particularly in the Middle
East, South Asia and parts of Africa, consanguinity remains common and in
some societies, it continues to be a culturally accepted and even preferred
practice.
Akkari Anthena
In recent years, Direct-To-Consumer (DTC) genetic testing has garnered
significant attention, offering individuals the ability to access their genetic
information without the need for a healthcare provider’s involvement.
Companies such as 23andMe, Ancestry DNA, and others have popularized
this concept, allowing consumers to gain insights into their ancestry, genetic
predispositions to health conditions, and traits. While DTC genetic testing
holds tremendous promise, it also presents a range of challenges that can
complicate its integration into clinical practice.
Bruce Stever
Consanguinity, the marriage or reproduction between individuals who
share a common ancestor, has been a common practice across many cultures
throughout history. In many societies, consanguinity is viewed as a way to
preserve familial ties, strengthen social bonds, or consolidate wealth and
resources. However, consanguinity can have significant genetic implications,
particularly when it comes to the inheritance of genetic diseases.
Krof Javana
Advancements in genomics and biotechnology have dramatically reshaped
our understanding of human health and disease. The field of clinical genetics,
which focuses on the genetic basis of health conditions and diseases, has
undergone a revolutionary transformation in recent years, driven by the rapid
progress in genetic sequencing technologies and the emergence of precision
medicine. Precision medicine refers to the tailoring of medical treatments and
interventions based on an individual’s genetic makeup, environment, and
lifestyle, moving away from the traditional “one-size-fits-all” approach. In this
new paradigm, clinical genetics plays a central role by providing insights into
the genetic underpinnings of disease, allowing healthcare providers to offer
more personalized and effective care.
Karenay Huttan
Mendelian inheritance, the foundational concept in genetics, describes
the inheritance patterns of traits and disorders based on the principles
established by Gregor Mendel in the 19th century. These principles, including
the laws of segregation and independent assortment, laid the groundwork
for understanding how genetic traits are passed down through generations.
In clinical genetics, Mendelian inheritance plays a pivotal role in diagnosing
and managing hereditary conditions, providing insights into the genetic
underpinnings of diseases that follow simple inheritance patterns.
Journal of Clinical & Medical Genomics received 391 citations as per Google Scholar report
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