Ting Li* and Gang Wu
High-flow oxygen inhalation, noninvasive and invasive ventilation were used for a 68-year-old female with laboratory-confirmed SARS-CoV-2 pneumonia successively. Secondary-infection, injury of liver and kidney, respiratory acidosis and coagulation disorder were revealed by laboratory findings. Two weeks after admission, chest radiograph showed pneumothorax. She died of respiratory failure four days later.
Anam Liaqat*, Muhammad Asad and Arif-Ullah Khan
Warfarin is an oral anticoagulant, which is commonly prescribed in hospital settings in various thrombotic conditions. It is known to have had a broad range of interactions with other medicinal gents widely used during clinical settings, particularly antibiotics, resulting in altered coagulation parameters and bleeding in such patients. In this study, we intend to describe two such cases that developed excessive hypoprothombinemic response due to cefoperazone and improved after substituting cefoperazone with alternative antibiotic. While there is no conclusive proof of warfarin-cefaperazone interactions, it is recommended that healthcare providers explore alternate antibiotic use in warfarin therapy patients and allow careful surveillance of the coagulation profile for all those patients receiving warfarin and antibiotics in combination with warfarin dosage modification.
Esayas Tekle*, Yonas Adisu, Sisay Teferi and Gemechu Tiruneh
DOI: 10.37421/2684-4559.2023.7.186
One of the most well-known human pathogens, Staphylococcus aureus, causes infections ranging from life-threatening conditions including sepsis, necrotizing pneumonia and, endocarditis to benign superficial skin infections. It was formerly thought to be an extracellular bacterium. However, it has been demonstrated that this pathogen can live and dwell inside cells. These features allow the pathogen to survive periods of antibiotic treatment or pressure from the immune system of the host and further enable it to start the infection once again after the environmental stress declines. Such characteristics are considered properties of Staphylococcus aureus small colony variants. Staphylococcus aureus small colony variants are often difficult to recognize due to the fact that they are endowed with unusual metabolic, physiological, and morphological characteristics that will cause difficulties for the routine diagnostic laboratory. As a result, they are associated with persistent infections.
Clinical Infectious Diseases: Open Access received 49 citations as per Google Scholar report
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