DOI: 10.37421/2157-7099.2023.14.682
Febrile neutropenia is a frequent complication in cancer patients and affects nearly 80% with hematological malignancies and 10%-50% with solid malignancies occurring most frequently during the first chemotherapy cycle. Bacterial Bloodstream Infections (BSIs) accounts for 10% to 25% of all febrile episodes and is considered the most common among the infectious complications in febrile neutropenic patients due to the lack of adequate inflammatory response and makes sepsis a significant cause of mortality in this particular setting.
Shinsuke Inoue, Keiji Sato, Shou Maruono, Haruto Nishida and Tsutomu Daa
Fluid Overload-Associated Large B-Cell Lymphoma (FO-LBCL) is a rare B-cell malignancy primarily found in body fluids without obvious mass formation or Human Herpes Virus type 8 (HHV-8) involvements. We report a case in which cell block specimens were useful for the diagnosis of FO-LBCL in the primary pericardial effusion of a human T-lymphotropic virus type 1 carrier patient. A 75-year-old man presented at our hospital complaining of fatigue and anorexia. Computed tomography revealed a massive pericardial effusion, but no mass lesions or enlarged lymph nodes. Analysis of the drained pericardial fluid revealed numerous solitary atypical cells with a high nuclear/cytoplasmic ratio and irregularly shaped nuclei of various sizes on Papanicolaou staining and blast-like and large atypical cells with multiple lobulated, clover-shaped and floating nuclei on Giemsa staining. Immunohistological staining of cell block specimens showed CD20 positivity and CD3 and HHV-8 negativity. The lesion was confined to the pericardial effusion and there was no obvious mass formation; hence, the patient was diagnosed with FO-LBCL. We observed the characteristic cytological features of FO-LBCL, such as clover-like or floating nuclei, in this case.
José Antonio
Cellular topography, the spatial distribution of cells within tissues, plays a crucial role in understanding tissue function and pathology. This article delves into the intricate cyto- and histopographic patterns of CPA3-positive cells, shedding light on their significance in various physiological and pathological contexts. CPA3, carboxypeptidase A3, serves as a marker for a distinct subset of cells with diverse functions in immunity, inflammation and tissue homeostasis. By elucidating the distribution of CPA3-positive cells across different tissues, this research provides valuable insights into their roles in health and disease.
Francisco Juan
Type 3 transformation zones present unique challenges in cervical cytology interpretation due to their dynamic nature and potential for discrepancies in sampling. This article explores the clinical significance of negative cytology results within Type 3 transformation zones, highlighting diagnostic considerations and implications for patient management. Through a comprehensive review of current literature and clinical insights, we aim to elucidate the complexities of interpreting negative cytology in Type 3 transformation zones and provide guidance for healthcare professionals in optimizing cervical cancer screening strategies.
Luis Ramón
Neurosurgical intraoperative histology techniques have significantly advanced in recent years, providing surgeons with real-time diagnostic information during surgical procedures. This abstract provides an overview of various techniques employed in intraoperative histology, including frozen section analysis, touch imprint cytology and rapid immunohistochemistry. These methods enable rapid pathological assessment of tissue samples, aiding in surgical decision-making and improving patient outcomes. Furthermore, emerging technologies such as stimulated Raman scattering microscopy and confocal microscopy offer high-resolution imaging capabilities, enhancing intraoperative tissue visualization. This abstract highlights the clinical relevance and utility of these techniques in guiding neurosurgical interventions, reducing operative time and minimizing the need for subsequent reoperations.
MarÃa Josefa
DNA methylation, an epigenetic modification crucial for gene regulation, exhibits remarkable heterogeneity across different tissues, developmental stages and individuals. This mosaic-like pattern of methylation plays a pivotal role in cellular identity, differentiation and disease susceptibility. Understanding the intricacies of this heterogeneity offers insights into fundamental biological processes and opens avenues for therapeutic interventions. This review delves into recent advancements in elucidating the complex landscape of DNA methylation mosaic, highlighting its implications in health and disease.
MarÃa Carmen
This comprehensive review delves into the intricate relationship between clinic-pathological features and immunohistochemical analysis. By synthesizing current research, it illuminates how immunohistochemistry enables a deeper understanding of disease processes, aiding in diagnosis, prognosis and therapeutic decision-making. From cancer to autoimmune disorders, the review navigates the diverse applications of this analytical tool, shedding light on its pivotal role in advancing clinical practice and enhancing patient care.
Teresa Carmen
Programmed Death-Ligand 1 (PD-L1) over-expression is a pivotal marker in immunotherapy response, yet its expression variability poses challenges in patient stratification and treatment efficacy prediction. This review delves into the multifaceted landscape of PD-L1 expression, elucidating factors contributing to its heterogeneity across diverse malignancies. We examine the influence of tumor microenvironment, genetic alterations and dynamic changes in PD-L1 expression over the course of treatment. Understanding the intricacies of PD-L1 variability is paramount for refining patient selection strategies and advancing personalized immunotherapy approaches.
Rafael Ãngel
Uterine Epithelioid Trophoblastic Tumor (ETT) is a rare form of gestational trophoblastic neoplasia, primarily affecting women of reproductive age. Characterized by its distinct histopathological features, including epithelioid trophoblastic cells, ETT presents diagnostic challenges due to its resemblance to other uterine tumors. Diagnosis typically involves histopathological examination supported by immunohistochemistry and molecular testing. Treatment strategies often comprise surgical intervention, chemotherapy and close surveillance due to the tumor's unpredictable behavior. Given its rarity, further research is essential to refine diagnostic criteria and optimize therapeutic approaches for improved patient outcomes. Uterine Epithelioid Trophoblastic Tumor (ETT) is a rare and aggressive form of Gestational Trophoblastic Neoplasm (GTN) arising from the placenta. While it represents only a small fraction of all trophoblastic tumors, its distinct histopathological features and clinical behavior warrant special attention. In this article, we delve into the characteristics, diagnostic methods and treatment approaches for uterine ETT, aiming to provide a comprehensive understanding of this condition.
Francisco Javier
This study delves into the intricate landscape of esophageal health, focusing on the assessment through endoscopic and histopathological findings. By examining a plethora of endoscopic images and histopathological specimens, the research elucidates various pathological conditions affecting the esophagus, including Gastroesophageal Reflux Disease (GERD), Barrett's esophagus, esophagitis and malignancies. Insights gleaned from this exploration not only aid in understanding the pathophysiology of these conditions but also inform clinical decision-making, guiding therapeutic interventions and enhancing patient care.
Journal of Cytology & Histology received 2334 citations as per Google Scholar report
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 