DOI: 10.37421/2157-7099.2023.14.682
Febrile neutropenia is a frequent complication in cancer patients and affects nearly 80% with hematological malignancies and 10%-50% with solid malignancies occurring most frequently during the first chemotherapy cycle. Bacterial Bloodstream Infections (BSIs) accounts for 10% to 25% of all febrile episodes and is considered the most common among the infectious complications in febrile neutropenic patients due to the lack of adequate inflammatory response and makes sepsis a significant cause of mortality in this particular setting.
Osman Jaffar*
Histopathology, the study of tissue changes associated with disease, plays an important and often indispensable role in forensic investigations. It is the field of medical science that deals with the microscopic examination of tissue samples to determine the presence, cause, and extent of disease or injury. In the context of forensic investigations, histopathology serves as a critical tool for pathologists, medical examiners, and forensic scientists in determining the cause and manner of death, as well as in identifying injuries or diseases that may not be visible to the naked eye. The role of histopathology in forensic science is multifaceted, encompassing everything from autopsy investigations to identifying toxins, diseases, or even post-mortem interval. Histopathological analysis provides valuable insights into the conditions that might lead to a person's death, thereby guiding legal and criminal investigations.
Boles Zou*
Cytogenetic plays a crucial role in the diagnosis, understanding, and treatment of various genetic disorders. It is a branch of genetics that focuses on the study of chromosomes, their structure, function, and behavior. Cytogenetics allows researchers and clinicians to observe chromosomal abnormalities, which can result in a wide range of diseases. These abnormalities may include changes in the number or structure of chromosomes, such as duplications, deletions, translocations, or inversions, all of which can lead to genetic disorders. The study of cytogenetic is integral to identifying the underlying causes of genetic diseases and provides insights into their pathogenesis, potential treatments, and management strategies.
Martins Garcia*
Histopathology is a crucial tool in understanding neurological disorders. By studying tissue samples under the microscope, histopathologists can provide valuable insights into the underlying mechanisms of diseases affecting the nervous system. Neurological disorders, ranging from neurodegenerative diseases like Alzheimer's and Parkinson's to stroke, epilepsy, and multiple sclerosis, can all be explored in depth through histopathological examination. The microscopic alterations in brain tissue provide essential information for diagnosis, prognosis, and the development of targeted therapies. These changes often reflect the complex interplay between genetic, environmental, and molecular factors, and the analysis of histopathological specimens helps to uncover the pathophysiology behind these disorders.
Rehder Tsuchiya*
Cytogenetic is a field of biology that focuses on the study of the structure and function of chromosomes. It combines aspects of genetics and cell biology to understand the role chromosomes play in inheritance, gene expression, and the manifestation of genetic disorders. At the heart of cytogenetic is the concept that our genetic makeup is housed within chromosomes, which are tightly packed structures made of DNA and proteins. These chromosomes are fundamental to the process of inheritance, as they carry the genetic instructions needed for the development, growth, and functioning of living organisms. The study of chromosomes has been pivotal in advancing our understanding of genetics, offering insights into a wide array of genetic conditions and diseases, from Down syndrome to various forms of cancer.
Chiara Rok*
Cell growth is a highly regulated process essential for normal development, tissue repair, and homeostasis within multicellular organisms. In healthy tissues, cell proliferation is balanced with cell death, ensuring that tissues and organs maintain their proper size and function. This balance is controlled by a complex network of signaling pathways, growth factors, and regulatory proteins. However, when this regulation is disrupted, it can lead to the uncontrolled proliferation of cells, a hallmark of cancer. Cancer arises when cells begin to grow and divide uncontrollably, forming tumors and eventually invading other parts of the body. The transformation from normal cell growth to uncontrolled proliferation is a multistep process that involves genetic mutations, epigenetic alterations, and aberrant signaling pathways. Understanding the link between cell growth and cancer is crucial for developing new therapeutic strategies to treat this devastating disease.
Castilletti Mori*
Immunofluorescence (IF) is a powerful and versatile laboratory technique that is extensively used in cancer research to study the presence, location, and interaction of proteins and other molecules within cells and tissues. It combines the specificity of antibodies with the sensitivity of fluorescence microscopy, enabling researchers to visualize and analyze molecular structures and cellular processes in situ. The technique has revolutionized cancer research by providing insights into tumor biology, helping to identify biomarkers for early diagnosis, and contributing to the development of targeted therapies. The application of immunofluorescence in cancer research has grown significantly over the past few decades, and its use continues to expand with the advent of new technologies and deeper understanding of cancer biology.
Archang Temdu*
Histopathology, the study of tissue samples under the microscope to understand disease, has become an indispensable tool in modern medicine. The integration of histopathology with personalized medicine is a promising frontier in the treatment of various diseases, particularly cancer. As technology advances, histopathology plays a critical role in identifying disease mechanisms, guiding treatment decisions, and offering insights into patientspecific characteristics that shape individualized therapeutic approaches. Personalized medicine, which tailors medical treatment to the individual characteristics of each patient, has seen exponential growth due to the detailed insights provided by histopathological examinations.
Caldrer Donini*
Immunofluorescence is a powerful and widely used technique that allows the visualization and localization of specific molecules within cells and tissues using antibodies conjugated to fluorescent dyes. It is an essential tool in both basic and clinical research, as well as diagnostics. The technique relies on the principle of antigen-antibody interaction, where a specific antibody is used to bind to its target antigen, and the antibody is tagged with a fluorescent molecule to enable detection through fluorescence microscopy. Immunofluorescence is highly versatile, allowing researchers to investigate the distribution, expression, and localization of proteins, nucleic acids, and other biomolecules with high sensitivity and spatial resolution.
Journal of Cytology & Histology received 2476 citations as per Google Scholar report
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