Pulmonary & Respiratory Medicine

James R. Klinger

James R. Klinger
Associate Professor
Alpert Medical School, Brown Medical School , USA

Biography

Dr. James Klinger is Associate Professor of Medicine at the Alpert Medical School of Brown University and Director of the Pulmonary Hypertension Center at Rhode Island Hospital. Dr. Klinger is a nationally recognized expert in the pulmonary circulation. His basic science research focuses on the role of the natriuretic peptides and cGMP in mediating pulmonary vascular smooth proliferation, pulmonary endothelial cell barrier function and right ventricular hypertrophic responses. Other basic science interest include the role of bone marrow-derived stem cells in mediating pulmonary vascular remodeling. Dr. Klinger’s clinical research has focused on new medical therapies for pulmonary arterial hypertension. He has been the site investigator on numerous industry sponsored trials and the principle investigator in several investigator initiated trials involving the safety and efficacy of phosphodiesterase inhibitors, natriuretic peptides, nitric oxide and prostacyclins in treating PAH.

Research Interest

1.Role of bone marrow-derived stem cells in mediating pulmonary vascular remodeling
2.Pulmonary endothelial cell barrier function
3.Pulmonary vascular smooth proliferation
4.Right ventricular hypertrophic responses
5.Medical therapies for pulmonary arterial hypertension
6.Venous Thromboembolism