Journal of Tissue Science and Engineering

Jan Oxholm Gordeladze

Jan Oxholm Gordeladze
Department of Biochemistry
University of Oslo, Norway

Biography

Jan Oxholm Gordeladze graduated from the Norwegian University of Technology and Natural Sciences NTNU in 1975 and became DOCTOR OF PHILOSOPHY University of Oslo Norway in 1981 His research and teaching skills have been evaluated as sufficient for professorships in physiology 1987 pharmacology 1991 and medical biochemistry 1991 Presently he works as professor of biochemistry at the Department of Biochemistry Institute of Basic Medical Sciences University of Oslo Norway Previous appointments include: Medical Director of MSD Norway Senior research Fellow Norwegian Research Council 19851988 Research Fellow Fulbright Scholar at The National Institutes of Health NIH/NIDDK with professor Allen M Spiegel 199091 Research Fellow at INSERM Unité 475 Montpellier France with professor Christian Jorgensen 199394 Professor at the Université Montpellier 1 and INSERM Unité 844 Montpellier France with professor Christian Jorgensen 20062009 Professor Gordeladze has tutored more than 25 PhD master andbachelor students and has been a reviewer of papers published in more than 20 different referenced journals.

Research Interest

Professor Jan O.Gordeladze’s research interests encompass hormonal and mechano-stimulatory control of cellular differentiation and metabolism, and include G-protein and growth factor mediated differentiation of stem cells to chondrocytes and osteoblasts, differentiation of peripheral blood monocytes to osteoclasts, and differentiation of naive T-cells to Th-1, Th-2, and Th-17 cells. A particular interest is taken in the interaction between differentiating stem cells, Th-cells, and osteoclasts related to phenotype acquisition and stability in a “cell engineering” setting (e.g. in inflamed joints) where the interaction between microRNA and transcription factor (TF) regulatory hierarchies plays a major role. Other (related) research interests are osteoporosis, the immunosuppressive effect of stem cells, the osteolytic effect of cancer cells, and finally the interaction of differentiating osteoblasts with osteoclasts in the engineering of osteoblasts in scaffolds used for bone replacement in general.