Metabolomics:Open Access

Jian Zhi Hu

Jian Zhi Hu
Senior Staff Scientist, Biological Science Division
Pacific Northwest National Laboratory, Washington State, USA

Biography

Dr. Hu is currently a Senior Staff Scientist and Principle Investigator of Pacific Northwest National Laboratory, Richland, Washington State, USA. He obtained his Ph.D. degree in applied physics in 1994 from a joint training program between the Chemistry Department of University of Utah and Wuhan Institute of Physics, the Chinese Academy of Sciences. Hu has 32 year’s research experience in solid state and liquid state nuclear magnetic resonance (NMR), magnetic resonance spectroscopy (MRS) and imaging (MRI). Dr. Hu is an author and co-author of more than 180 peer-reviewed publications in scientific journals, books, and encyclopedias, and has given a large number of oral presentations and posters at scientific conferences. His h-Index is 30. He received two US R&D 100 awards and 10 issued US patents.

Research Interest

Dr. Hu’s major research focuses on new NMR capability development aimed at pushing the frontier of NMR and the applications of NMR to address critical problems in the fields of biomedical science, catalysis science, and energy storage, etc. He pioneered the Combined High Temperature and High Pressure MAS NMR technique for in situ NMR investigations of reaction mechanism/dynamics, and a range of slow and ultra slow magic angle spinning, or magic angle turning (MAT) NMR techniques with sample spinning rate ranged from 1 to about 1000 Hz for enhanced spectral resolution in solids, semi-solids and biological materials. His current research interests and expertise include (i) Developing magic angle spinning NMR metabolomics, in particular slow-MAS metabolomics, for biomedical applications; (ii) in situ and ex situ NMR characterization of heterogeneous solid catalyst materials, surface functional groups and active cites, molecular dynamics at the interface, reaction mechanisms and pathways; (iii) in situ constant flow and high pressure MAS NMR capability development; (iv) in situ NMR capability development for energy storage systems such as Li-ion and beyond Li-ion batteries; (v) ultra-high field NMR spectroscopy, quantum chemistry calculations to predict molecular geometry and the principal values of chemical shift tensors, and quadrupolar coupling constants; (vi) NMR lineshape simulation, NMR pulse sequence design, programming, and testing.